I would like to inform you that we have been using PulsePen during the latest months and have started a physiological study about the impact of gravitational stress on PWV. Our previous experience was with the AtCor tonomoter, but PulsePen is by far more reliable, comfortable and easy to use. We are using two tonometers to calcualte the PWV, and the precisión is incredible (always < 0.5 m/s). Exporting and analyzing the signal is easy and tasks can be accomplished in few seconds. I’ve been using my own Matlab script for performing the PWA, but this was only due to the need of calculating ventriculo-arterial coupling. Some of my methods for detecting points of interests in the pressure waveform could be of your interest. If your interested in my Matlab script, I will be very Happy to share with you. I’m a ICU physician withot any knowledge of programming, but with good skills for learning. So, during the last three months I’ve been using this language for own purposes. And I’m proud to say that it works really well. I’ve also checked in your webpage that you have reléase a holder for the tonometer. I’m interest on acquiring one of them. So, could you tell me how much it cost, please? Thank you again, and congratulation for such a wonderfull piece of art. Best wishes, Ignacio Dr. M. Ignacio Monge García Servicio de Cuidados Críticos y Urgencias Hospital SAS de Jerez C/ Circunvalación s/n. 11408 Jerez de la Frontera, Spain I have been using the PulsePen device for years, and have followed the constant improvement of the product technology and the user-friendly interface of the program. For the purpose of SEVR measurement, I suggest that it should be clearer in the graphics which is the threshold value of danger for the patient and what is the gray area in which there could be an increased risk to develop a myocardial ischemia for the patient. Congratulations to the developers of this excellent product. Dr. Andrea Grillo, MD, PhD Sc Medicina Clinica - ASUGI Trieste, Italy PulsePen by Diatecne is a device that we have been using for many years. The device is innovative in its shape and handling compared to other instruments from other brands offering arterial stiffness measurement. Learning how to use it is easy. Operators can thus be efficient quickly. The absence of wires is a real asset for both the patient and the operator. Signal quality is excellent. Data processing is easy. I highly recommend this tool both for routine care but also for research performance (work on signals). Pr Laure Joly Université de Lorraine CHRU-Nancy, Geriatric Ward, INSERM U1116 F-54000 Nancy, France